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sterol 14α-demethylase
Cat No.
EXWM-0877
Description
This heme-thiolate (P-450) enzyme acts on a range of steroids with a 14α-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses two successive hydroxylations of the 14α-methyl group, followed by elimination as formate, leaving a 14(15) double bond.
Form
Liquid or lyophilized powder
Enzyme Commission Number
CAS No.
60063-87-8
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
obtusufoliol 14-demethylase; lanosterol 14-demethylase; lanosterol 14α-demethylase; sterol 14-demethylase
Reaction
a 14α-methylsteroid + 3 O2 + 3 NADPH + 3 H+ = a Δ14-steroid + formate + 3 NADP+ + 4 H2O
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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