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Splitomicin
Cat No.
CEI-0498
Description
Potent inhibitor of yeast NAD⁺dependent histone deacetylase Sir2p (IC50 = 60 µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
Appearance
Lyophilized solid
Product Overview
A HDAC inhibitor
CAS No.
5690-03-9
Molecular Weight
513.49
Purity
>95% by HPLC
Storage
-20 centigrade
Targets
HDAC
Molecular Formula
C₁₃H₁₀O₂
Chemical Name
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Solubility
DMSO (200 mg/ml)
Shipping Conditions
Gel pack
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