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Spautin-1
Cat No.
CEI-0693
Description
Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 blocks the prosurvival autophagy pathway in cancer cells.
Appearance
White to off-white solid
Product Overview
An USP10 and USP13 inhibitor
CAS No.
1262888-28-7
Molecular Weight
198.2
Purity
>98%
Storage
-20 centigrade
Targets
USP10, USP13
Molecular Formula
C 15 H 11 F 2 N 3
Chemical Name
6-Fluoro-N-(4-fluorobenzyl)quinozaline-4-amine
Solubility
DMSO (100 mg/ml)
Shipping Conditions
RT
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