Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
Smo Antagonist, SA1
Cat No.
CEI-0659
Description
A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC50 = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Appearance
Liquid
Product Overview
A Smoothened (Smo) antagonist
Molecular Weight
873.99
Purity
>95% by HPLC
Storage
-20 centigrade
Targets
SMO
Molecular Formula
C 26 H 29 FN 4 O 2
Chemical Name
3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Shipping Conditions
Gel pack
Download
Download Datasheet