Description
A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC50 = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Product Overview
A Smoothened (Smo) antagonist
Molecular Formula
C 26 H 29 FN 4 O 2
Chemical Name
3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Shipping Conditions
Gel pack
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