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Smad3 Inhibitor, SIS3

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Cat No.

CEI-0657

Description

A potent and selective inhibitor of Smad3 function. SIS3 selectively inhibits TGF-β1/ALK5-induced Smad3 phosphorylation. Also inhibits the TGF-β1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site.

Appearance

Pale yellow solid

Product Overview

A Smad3 inhibitor

CAS No.

521984-48-5

Molecular Weight

406.44

Purity

>90% by NMR

Storage

-20 centigrade

Targets

SMAD3

Molecular Formula

C 28 H 27 N 3 O 3 . HCl

Chemical Name

(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

Solubility

DMSO

Shipping Conditions

Gel pack