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SKPin C1
Cat No.
CEI-0689
Description
Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.
Appearance
Beige solid
Product Overview
An ubiquitin E3 ligase inhibitor
CAS No.
432001-69-9
Molecular Weight
479.81
Purity
>90% by HPLC
Storage
-20 centigrade
Targets
RBX1
Molecular Formula
C18H13BrN2O4S2
Chemical Name
2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Solubility
DMSO ( 100 mM)
Shipping Conditions
Gel pack
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