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SIRT2 Inhibitor, AGK2

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Cat No.

CEI-0651

Description

A potent inhibitor of sirtuin 2 (SIRT2) (IC50 = 3.5 µM). AGK2 is>15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α ;-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease.

Appearance

Yellow solid

Product Overview

A SIRT2 inhibitor

CAS No.

304896-28-4

Molecular Weight

367.44

Purity

>98% by HPLC

Storage

-20 centigrade

Targets

SIRT2

Molecular Formula

C₂₃H₁₃Cl₂N₃O₂

Chemical Name

AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide

Solubility

DMSO

Shipping Conditions

Gel pack