Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
SIRT1 Inhibitor, EX-527
Cat No.
CEI-0647
Description
A potent SIRT1 inhibitor (IC50 = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.
Appearance
Off-white solid
Product Overview
A SIRT1 inhibitor
CAS No.
49843-98-3
Molecular Weight
205.22
Purity
>97% by HPLC
Storage
-20 centigrade
Targets
SIRT1
Molecular Formula
C₁₃H₁₃ClN₂O
Chemical Name
EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Solubility
DMSO (>10 mg/ml) or H₂O (>10 mg/ml)
Shipping Conditions
Gel pack
Download
Download Datasheet