Description
A potent SIRT1 inhibitor (IC50 = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.
Appearance
Off-white solid
Product Overview
A SIRT1 inhibitor
Molecular Formula
C₁₃H₁₃ClN₂O
Chemical Name
EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Solubility
DMSO (>10 mg/ml) or H₂O (>10 mg/ml)
Shipping Conditions
Gel pack
Download Datasheet