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Simeprevir
Cat No.
CEI-1527
Product Overview
Simeprevir is a potent inhibitor of HCV NS3/4A protease with Ki value of 0.36 nM. The hepatitis C virus (HCV) NS3/4A protease is a serine protease encoded by HCV and is responsible for cleavage at four sites of the HCV polyprotein. It is essential for viral replication. In Huh-7-Rep cells, Simeprevir inhibited HCV replication with EC50 of 7.8 nM. In the Huh7-Luc HCV genotype 1b replicon cell line, Simeprevir inhibited HCV replication with EC50 and EC90 values of 8 nM and 24 nM respectively in a dose dependent way. In ninety-two naive, HCV genotype 1-infected patients, treatment with Simeprevir (50 or 100 mg QD) for 12 or 24 weeks and peginterferon α-2a/ribavirin (PegIFNα-2a/RBV) for 24 or 48 weeks or PegIFN α-2a/RBV for 48 weeks lonely (PR48 group), RNA reductions in the 4 week were-5.2,-5.2 and-2.9 log10IU/mL for Simeprevir 50 mg combined, 100 mg combined and PR48 groups, respectively, which suggested Simeprevir reduced HCV RNA more rapidly and substantially. Also, Simeprevir increased the virologic response rate.
CAS No.
923604-59-5
Molecular Weight
749.96
Purity
0.9995
Storage
Store at -20°C
Synonyms
TMC435,TMC435350,TMC-435350,Simeprevir
Targets
HCV NS3/4A protease
Molecular Formula
C38H47N5O7S2
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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