events
Mark your calendar for November 19-21 and meet us at Fi Europe 2024, Messe Frankfurt, Germany. We look forward to connecting with you at this exciting event!
Learn More >>
Products

Enzymes for Research, Diagnostic and Industrial Use

Products
Online Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

24 hour
Promise

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

SB743921

Cat No.
CEI-1521
Description
SB743921 is an inhibitor of kinesin spindle protein (KSP) with a Ki value of 0.1 nM.
Product Overview
SB743921 is an inhibitor of kinesin spindle protein (KSP) with Ki value of 0.1nM. As an inhibitor of mitotic kinesin KSP, SB743921 causes cell cycle arrest in mitosis, results in cell death. SB743921 is developed to treat for cancers. SB743921 is a potent and selective inhibitor. In the affinity assays, SB743921 shows Ki values of 0.1nM and 0.12nM for human KSP and mouse KSP, respectively. It has no affinity with other kinesins. In the cellular assay, SB743921 exerts anti-proliferation efficacy in SKOV3, Colo205, MV522 and MX1 with IC50 values of 0.02nM, 0.07nM, 1.7nM and 0.06nM. Moreover, SB743921 is shown to have activity against human tumor xenografts Colo205, MCF-7, SK-MES, H69, OVCAR-3, HT-29, MDA-MB-231 and A2780.SB743921 is also effective against P388 lymphocytic leukemia xenografts in mice.
CAS No.
940929-33-9
Molecular Weight
553.53
Purity
0.98
Storage
Store at-20°C
Targets
KSP (MX1 cells); KSP (Colo205 cells); KSP; KSP (SKOV3 cells); KSP (MV522 cells); KSP (P388 cells)
IC50
0.06 nM; 0.07 nM; 0.1 nM(Ki); 0.2 nM; 14.4 nM; 14.4 nM
Molecular Formula
C31H34Cl2N2O3
Chemical Name
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide; hydrochloride
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

Our Products Cannot Be Used As Medicines Directly For Personal Use.

0
Click unfold / close
Inquiry Basket
Delete selected Quote Check Out
Decide to move out of the shopping cart?
Sure No, Back

Please choose product!

< Go Back
You have already added to buy this product