Description
SB 203580 can inhibit p38 MAPK with IC50 of 300 nM.
Alias
SB-203580, SB203580
Storage
2 years at -20centigrade Powder
Synonyms
SB-203580, SB203580
Molecular Formula
C21H16FN3OS
Chemical Name
4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine
Solubility
DMSO 76 mg/mL, Water
In vitro
SB 203580 is a specific inhibitor of a MAP kinase, which can inhibit reactivating kinase (RK) with IC50 of 0.6 uM. SB 203580 suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of heat shock protein (HSP) 27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo.
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