Description
SB 202190 (FHPI) can potently inhibit p38alpha and p38beta with IC50 of 50 nM and 100 nM.
Storage
2 years at -20 centigrade
Targets
p38alpha, p38beta
Molecular Formula
C20H14N3OF
Chemical Name
4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)phenol
Solubility
DSMO 66 mg/mL Water
In vitro
SB 202190 significantly inhibits both basal and anti-Fas antibody-induced MAPKAPK 2 activity in a dose-dependent manner. SB 202190 strongly inhibits UVB induced COX-2 protein expression in HaCaT cells, and markedly inhibits UVB induced cox-2 mRNA. SB 202190 treatment enhances the growth of THP-1 and MV4-11 cells. SB 202190 increases the phosphorylation of c-Raf and ERK, suggesting that Ras-Raf-MEK-mitogen-activated protein kinase (MAPK) pathway activation is involved in the leukemia cell growth induced by SB 202190.
In vivo
In the endotoxin model of sepsis, SB 202190 treatment produces a statistically significant survival benefit compared with control.
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