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Rapamycin(Sirolimus)
Cat No.
CEI-0124
Description
Rapamycin(Sirolimus) can inhibit mTOR with IC50 of 0.1 nM.
CAS No.
53123-88-9
Molecular Weight
914.18
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
mTOR
Molecular Formula
C51H79NO13
Chemical Name
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-ep
Solubility
DMSO 20 mg/mL Water
In vitro
Rapamycin can potently inhibit mTOR kinase with IC50 of 0.1 nM by binding to 12-kDa FK506- and rapamycin-binding protein (FKBP12, or FKBP) and the FKBP-rapamycin binding (FRB) domain of mTOR. Rapamycin is also an immunosuppressive drug. Rapamycin induced autophagy but not apoptosis in rapamycin-sensitive malignant glioma U87-MG and T98G cells by inhibiting the function of mTOR.
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