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Ramelteon(TAK-375)

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Cat No.

CEI-0213

Description

Ramelteon(TAK-375)

Alias

Rozerem, TAK-375

CAS No.

196597-26-9

Molecular Weight

259.34

Purity

>99%

Storage

2 years at -20 centigrade

Synonyms

Rozerem, TAK-375

Targets

MT1 receptor, MT2 receptor, MT receptor (chicken)

Molecular Formula

C16H21NO2

Solubility

In vitro

Ramelteon (TAK-375) can inhibit MT1 receptor and MT2 receptor with Ki of 14 pM and 112 pM. Ramelteon has high affinity with recombinant human MT1 and MT2 receptors with pKi of 10.05 and 9.70. Ramelteon (1 nM) increases ERK1/2 phosphorylation not only in MT1/MT2 cerebellar granule cells but also in cerebellar granule cells expressing only one of the two melatonin receptors.