Description
Raloxifene HCl
Alias
LY156758, Keoxifene, Evista
Storage
2 years at -20centigrade Powder
Synonyms
LY156758, Keoxifene,Evista
Targets
estrogen receptors
Molecular Formula
C28H27NO4S.HCl
Chemical Name
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1- ylethoxy)phenyl]methanone
Solubility
DMSO 102 mg/mL, Water
In vitro
Raloxifene, has been demonstrated as a potent uncompetitive inhibitor of human liver aldehyde oxidase-catalyzed oxidation of phthalazine, vanillin, and nicotine-Delta1(5)-iminium ion, with Ki values of 0.87 nM, 1.2 nM and 1.4 nM. Raloxifene has also been shown to be a noncompetitive inhibitor of an aldehyde oxidase-catalyzed reduction reaction of a hydroxamic acid-containing compound, with a Ki of 51 nM. Raloxifene activates TGF beta 3 promoter as a full agonist at nanomolar concentrations, and raloxifene inhibits the estrogen response element-containing vitellogenin promoter expression as a pure estrogen antagonist in transient transfection assays.
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