Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
Raloxifene HCl
Cat No.
CEI-0350
Description
Raloxifene HCl
Alias
LY156758, Keoxifene, Evista
CAS No.
84449-90-1
Molecular Weight
510.04
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
LY156758, Keoxifene,Evista
Targets
estrogen receptors
Molecular Formula
C28H27NO4S.HCl
Chemical Name
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1- ylethoxy)phenyl]methanone
Solubility
DMSO 102 mg/mL, Water
In vitro
Raloxifene, has been demonstrated as a potent uncompetitive inhibitor of human liver aldehyde oxidase-catalyzed oxidation of phthalazine, vanillin, and nicotine-Delta1(5)-iminium ion, with Ki values of 0.87 nM, 1.2 nM and 1.4 nM. Raloxifene has also been shown to be a noncompetitive inhibitor of an aldehyde oxidase-catalyzed reduction reaction of a hydroxamic acid-containing compound, with a Ki of 51 nM. Raloxifene activates TGF beta 3 promoter as a full agonist at nanomolar concentrations, and raloxifene inhibits the estrogen response element-containing vitellogenin promoter expression as a pure estrogen antagonist in transient transfection assays.
Download
Download Datasheet