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RAF265 (CHIR-265)
Cat No.
CEI-0170
Description
RAF265 (CHIR-265) can inhibit b-Raf and VEGFR2 with IC50 of 3 nM and 60 nM.
CAS No.
927880-90-8
Molecular Weight
518.41
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
b-Raf, VEGFR2
Molecular Formula
C24H16F6N6O
Chemical Name
1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine
Solubility
DMSO 104 mg/mL Water
In vitro
RAF265 can inihbit RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 uM. Raf265 show inhibition to the growth of advanced human melanoma tumors. Raf265 significantly enhanced TRAIL (tumour-selective death receptor ligand tumour necrosis factor-related apoptosis-inducing ligand) sensitivity in NCI-H727 and CM insulinoma cells. Raf265 strongly decreased Bcl-2 levels in those cell lines susceptible to its TRAIL-sensitizing action by blocking Raf-MEK-Erk signaling.
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