Description
R1479 (4-azidocytidine) is a potent and highly specific inhibitor of HCV replication with an IC50 value of 1.28 μM in the HCV subgenomic replicon system.
Product Overview
R1479 is a specific inhibitor of HCV replication in cell culture with IC50 value of 1.28 μM. Hepatitis C virus (HCV) is an enveloped (+)-single stranded RNA virus, and the viral RNA is replicated in host cell via RNA-dependent RNA polymerase of HIV, which is the cause of hepatitis C and some cancer lymphomas. R1479 is a potent and specific inhibitor of HCV NS5B RNA polymerase to inhibit HCV replication in the HCV subgenomic replicon system. In proliferating replicon cells of 2209-23 cell line, 72 h incubation of R1479 showed inhibition of HCV RNA replication (IC 50 = 1.28 μM), which had the similar potency with 2_-C-methylcytidine (IC 50 = 1.13 μM). R1479 had no influence on cell proliferation and viability of Huh-7 cells at concentration up to 2 mM, which suggested the inhibition by R1479 was a direct antiviral mechanism. Furthermore, prolong incubation of R1479 for HCV replicon cells led to a continuous reduction of HCV RNA to an undetectable level within 15 days of incubation. Finally, R1479 showed no cytotoxicity in replicon cells.
Synonyms
R 1479; 4-Azidocytidine; R1479
Molecular Formula
C9H12N6O5
Chemical Name
4-amino-1-[(2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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