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Puromycin Dihydrochloride
Cat No.
CEI-0634
Description
A nucleoside antibiotic. It inhibits protein synthesis by disrupting peptide transfer on ribosomes causing premature chain termination during translation. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to puromycin is conferred by the puromycin N-acetyl-transferase gene (pac) from Streptomyces. Puromycin has a fast mode of action, causing rapid cell death at low antibiotic concentrations. Adherent mammalian cells are sensitive to concentrations of 2 to 5 µg /ml, while cells in suspension are sensitive to concentrations as low as 0.5 to 2 µg /ml
Appearance
Liquid
Product Overview
A protein synthesis inhibitor
CAS No.
58-58-2
Molecular Weight
156.22
Purity
>98%
Storage
-80 centigrade
Targets
Protein Synthesis
Molecular Formula
C₂₂H₂₉N₇O₅ · 2HCl
Chemical Name
3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride
Shipping Conditions
Dry Ice
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