Description
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not hydrolyse proluteinizing-hormone-releasing-hormone. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 2. In peptidase family S8 (subtilisin family)
Form
Liquid or lyophilized powder
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
prohormone convertase 3; neuroendocrine convertase 1; PC1
Reaction
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg┼ bonds
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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