Description
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
Storage
2 years -20 centigrade Powder; 2 weeks 4 centigrade in DMSO; 6 months -80 centigrade in DMSO.
Molecular Formula
C18H16ClN3O2
Chemical Name
N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-
Solubility
DMSO 32 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
In vitro
PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells.
In vivo
PQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner.
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