Pimobendan can selectively inhibit PDE3 with IC50 of 320 nM. Pimobendan inhibits the activity of cAMP-PDE III with IC50 of 2.4 uM. It also exerts concentration-dependent positive inotropic effects in isolated guinea-pig papillary muscles with a potency (EC50) of 6.0 uM, which is partly due to selective cardiac PDE III inhibition.
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