Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
PIK-90
Cat No.
CEI-0091
Description
PIK-90 can inhibit PI3Kalpha, PI3Kbeta, PI3Kdelta and PI3Kgamma with IC50 of 11 nM, 350 nM, 58 nM and 18 nM.
CAS No.
677338-12-4
Molecular Weight
351.36
Purity
>99%
Storage
2 years at -20 centigrade
Targets
PI3Kalpha
Molecular Formula
C18H17N5O3
Solubility
DSMO 0.28 mg/mL Water
In vitro
PIK-90 is unique in their potencies for inhibiting PI3Kgamma in vitro.Treatment of dHL60 cells with PIK-90 impairs consolidation and stability of the leading edge formed after treatment with uniform fMLP(chemoattractants like f-Met-Leu-Phe). PIK-90 is a potnet PI3K-alpha inhibitor and can potently block phosphorylation of Akt.PIK-90 induced a modest G0/G1 arrestat a concentration of 0.5 uM sufficient to inhibit phosphorylation of Akt substantially. PIK-90 is a potent inducer of CLL cell apoptosis. In chronic lymphocytic leukemia (CLL), PI-103 can induce a significant reduction of chemotaxis and actin polymerization to CXCL12 and reduced migration beneath marrow stromal cells by inhibiting phosphorylation of Akt and S6.
In vivo
PIK-90 can significant increase in IgG1/IgE double-positive cells and lead to markedly enhanced B-cell switch to IgE by inhibiting PI3K in vivo. In human glioblastoma xenografts, PIK-90 and Roscovitine, in combination, can acted in a synthetic-lethal manner to induce apoptosis.
Download
Download Datasheet