Description
Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.
Applications
An inhibitor of Cox
Molecular Formula
C19H20N2O2
Melting Point
106-108° C (lit.)
Solubility
Soluble in water (1 mg/ml at 25° C), ethanol (62 mg/ml at 25° C), methanol, DMSO (62 mg/ml at 25° C), and DMF (25 mg/ml).
Boiling Point
~424.9° C at 760 mmHg (Predicted)
Refractive Index
1.86 (Predicted)
Density
2.02 g/cm3 (Predicted) (tautomer)
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