Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
PHA-665752
Cat No.
CEI-0075
Description
PHA-665752 can inhibit c-MET with IC50 of 9 nM.
CAS No.
477575-56-7
Molecular Weight
641.61
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
c-MET
Molecular Formula
C32H34Cl2N4O4S
Chemical Name
(R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one
Solubility
DMSO 128 mg/mL Water
In vitro
PHA-665752 can inhibit c-MET with IC50 of 9 nM. For cell lines:(1) PHA-665752 can decrease the numbers of premalignant lung lesions and induced apoptosis in tumor cells and vascular endothelial cells within lesions.PHA-665752 induced apoptosis of a lung adenocarcinoma cell line derived from Kras(LA1) mice (LKR-13) and a murine lung endothelial cell line (MEC). And PHA-665752 inhibited lung tumorigenesis in Kras(LA1) mice. (2) PHA-665752 triggers massive apoptosis in 5 of 5 gastric cancer cell lines with MET amplification.
Download
Download Datasheet