Description
This enzyme, derived from the house dust mite, is a major component of the allergic immune response. The substrate specificity of this enzyme is not altogether clear. It cleaves the low-affinity IgE receptor CD23 at Glu298┼Ser299 and Ser155┼Ser156. It also cleaves the pulmonary structural proteins occludin and claudin at Leu┼Leu, Asp┼Leu and at Gly┼Thr bonds. It can also cleave the α subunit of the interleukin-2 (IL-2) receptor (CD25). Using a positional scanning combinatorial library, it was found that the major substrate-specificity determinant is for Ala in the P2 position. The enzyme shows only a slight preference for basic amino acids in the P1 and P3 positions and a preference for aliphatic amino acids such as Ile, Pro, Val, Leu and norleucine in the P4 position.Belongs in peptidase family C1A.
Form
Liquid or lyophilized powder
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
allergen Der f 1; allergen Der p 1; antigen Der p 1; antigen Eur m 1; antigen Pso o 1; major mite fecal allergen Der p 1; Der p 1; Der f 1; Eur m 1; endopeptidase 1 (mite)
Reaction
Broad endopeptidase specificity
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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