Description
Pemetrexed disodium (Alimta) can inhibit TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM.
Storage
2 years at -20 centigrade
Molecular Formula
C20H19N5Na2O6
Chemical Name
sodium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate
Solubility
DSMO 1 mg/ml Water 94 mg/mL Ethanol
In vitro
Pemetrexed disodium (Alimta) can inhibit TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM. Cisplatin plus Pemetrexed combined with SOCS-1 gene delivery shows the antitumor effect by inhibition of cell proliferation, invasiveness, and induction of apoptosis in MPM cells
In vivo
Pemetrexed disodium produces a duration-dependent tumor growth delay (TGD) in the human H460 non-small cell lung carcinoma xenograft.
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