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PD153035 hydrochloride
Cat No.
CEI-1462
Description
PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM.
Product Overview
PD153035 (4-(3-Bromoanilino)-6,7-dimethoxyquinazoline) is an extremely potent epidermal growth factor receptor (EGFR) inhibitor that competitively binds at the ATP site with the half maximal inhibition concentration IC50 of 0.025 nM resulting in the inhibition of the tyrosine kinase activity of the EGFR. PD153035 has been found to inhibit EGF-dependent EGFR phosphorylation in a variety of human cancer cell lines over-expressing EGFRs, which include A431, Difi, DU145, MDA-MB-468, ME180 and C4i, with IC50 of 0.22 μM, 0.3 μM, 0.4 μM, 0.68 μM, 0.95 μM and 2.5 μM respectively leading to suppression of proliferation and clonogenicity in those cell lines. Besides exerting potent inhibition against EGFRs, PD153035 also inhibits the closely related HER2/neu receptor but to a lesser degree
CAS No.
153436-54-5
Molecular Weight
396.67
Purity
0.97
Storage
Store at RT
Synonyms
ZM252868,PD153035 HCL
Targets
EGFR
IC50
5.2 pM (Ki); 29 pM
Molecular Formula
C16H14BrN3O2.HCl
Chemical Name
N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine
Solubility
Limited solubility
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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