Description
PD 98059 can inhibit MEK1 and MEK2 with IC50 of 4 uM and 50 uM.
Storage
2 years at -20centigrade Powder
Molecular Formula
C16H13NO3
Chemical Name
2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one
Solubility
DMSO 19 mg/mL Water
In vitro
PD-98059 can inhibit MEK1 and MEK2 with IC50 of 4 uM and 50 uM. PD98059 does not change either the stabilization or DNA binding ability of HIF-1alpha but it inhibits the trans-activation ability of HIF-1alpha, thereby it reduces the hypoxia-induced transcription.
In vivo
(1) In human luteinized granulosa cells Inhibition of mitogen-activated protein (MAP) kinase kinase (MEK) with PD98059 in human luteinized granulosa cells will block epidermal growth (EGF)-stimulated MAP kinase activity and induce apoptosis. (2) In acute myeloid leukemia (AML) PD98059, an inhibitor of MAPKinase kinase (MEK) which activates MAPKinase, inhibited this transient ERK phosphorylation, but was unable to block maturation as measured by acquisition of CD15 in acute myeloid leukemia (AML). (3)Axonal growth PD98059 ([2-(2amino-3-methoxyphenyl)-oxanaphthalen-4-one]) blocks mitogen activated protein kinase and leave spontaneous axonal outgrowth unaffected with 50 uM by inhibiting nerve growth factor stimulated axon growth because nerve growth factor stimulated axonal outgrowth in vitro from adult mouse dorsal root ganglia utilizes the mitogen activated protein kinase pathway.
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