Description
A 400-kDa disulfide-linked dimer. Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase. The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold. In peptidase family M43.
Form
Liquid or lyophilized powder
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
insulin-like growth factor binding protein-4 protease; pregnancy-associated plasma protein-A
Reaction
Cleavage of the Met135┼Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143┼Lys bond in IGFBP-5
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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