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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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PAC-1

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Cat No.

CEI-0986

Description

Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 µM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 µM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 µM respectively). PAC-1 had an IC50 value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue IC50 values of 3.2-8.5 µM were observed

Abbr

PAC-1

Appearance

A crystalline solid.

CAS No.

315183-21-2

Molecular Weight

392.5 Da

Purity

>99%

Stability

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Targets

Protease

Molecular Formula

C23H28N4O2

Solubility

Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO

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