Description
ONO-AE3-208(AE 3-208) is an antagonist of EP4.
Product Overview
ONO-AE3-208 is an inhibitor of EP4.EP4 is one of the prostaglandin E2 receptors and is associated with inflammatory disease and cancer such as prostate cancer. As an antagonist of EP4, ONO-AE3-208 is expected to be a potential therapy for prostate cancer. In vitro assays show that ONO-AE3-208 can suppress the migration and invasion of prostate cancer cells. 10μM of ONO-AE3-208 decreases wound healing proportion of PC3 and LNCaP cell lines in wound-healing assay. And in Transwell Invasion assay, ONO-AE3-208 inhibits cell invasion even at concentration of 0.1μM. ONO-AE3-208 is also reported to suppress bone metastasis in vivo. Since activation of E2 can increase the expression of matrix metalloproteinase (MMP) and release inflammatory cytokines, and then exacerbates abdominal aortic aneurism (AAA) formation, ONO-AE3-208 is also used in the studies of AAA formation. It has been proved that ONO-AE3-208 can cause the elastic fiber degradation and inhibit AAA formation in vivo in a dose-dependent manner.
Synonyms
AE 3-208; ONO AE3 208
Molecular Formula
C24H21FN2O3
Chemical Name
4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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