Description
NVP-AEW541 can inhibit IGF-IR and InsR with IC50 of 86 nM and 2300 nM.
Storage
2 years at -20centigrade Powder
Molecular Formula
C27H29N5O
Chemical Name
7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Solubility
DMSO 88 mg/mL Water
In vitro
As a pyrrolo[2,3-d]pyrimidine derivative small molecular weight kinase inhibitor, NVP-AEW541 can inhibit IGF-IR and InsR with IC50 of 86 nM and 2300 nM.
In vivo
In vivo, NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. NVP-AEW541 induced a G1 cell cycle block in all cells tested, whereas apoptosis was observed only in those cells that show a high level of sensitivity. Oral administration of NVP-AEW541 (50 mg/kg twice daily) inhibited tumor growth of neuroblastoma xenografts in nude mice.
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