Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
NVP-AEW541
Cat No.
CEI-0042
Description
NVP-AEW541 can inhibit IGF-IR and InsR with IC50 of 86 nM and 2300 nM.
Alias
AEW541
CAS No.
475489-16-8
Molecular Weight
439.55
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
AEW541
Targets
IGF-IR, InsR
Molecular Formula
C27H29N5O
Chemical Name
7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Solubility
DMSO 88 mg/mL Water
In vitro
As a pyrrolo[2,3-d]pyrimidine derivative small molecular weight kinase inhibitor, NVP-AEW541 can inhibit IGF-IR and InsR with IC50 of 86 nM and 2300 nM.
In vivo
In vivo, NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. NVP-AEW541 induced a G1 cell cycle block in all cells tested, whereas apoptosis was observed only in those cells that show a high level of sensitivity. Oral administration of NVP-AEW541 (50 mg/kg twice daily) inhibited tumor growth of neuroblastoma xenografts in nude mice.
Download
Download Datasheet