Description
NU7441 (KU-57788) can inhibit DNA-PK with IC50 of 14 nM.
Storage
2 years at -20centigrade Powder
Molecular Formula
C25H19NO3S
Chemical Name
4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-
Solubility
DMSO 3 mg/mL Water
In vitro
NU7441 can inhibit the DNA repair enzyme DNA-dependent protein kinase (DNA-PK) with IC50 of 14 nM. Due to DNA-PK inhibition, NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells. NU7441 can retard the repair of ionizing radiation-induced and etoposide-induced DSB.
In vivo
NU7441 increased G(2)-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 increased etoposide-induced tumor growth delay 2-fold without exacerbating etoposide toxicity to unacceptable levels.
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