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NSC 74859 (S3I-201)
Cat No.
CEI-0199
Description
S3I-201(NSC 74859) inhibits Stat3-Stat3 complex with IC50 of 86 uM.
CAS No.
501919-59-1
Molecular Weight
365.36
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
STAT3
Molecular Formula
C16H15NO7S
Chemical Name
2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid
Solubility
DMSO 73 mg/mL, Water
In vitro
S3I-201(NSC 74859) inhibits Stat3-Stat3 complex formation and Stat3 DNA-binding and transcriptional activities. S3I-201 inhibits Stat3 DNA-binding activity with IC50 of 86 uM. S3I-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3.
In vivo
S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo. Tumor growth can be inhibited by S3I-201 Human breast (MDA-MB-231) tumor-bearing mice were given S3I-201 (5 mg/kg) i.v. every 2 or every 3 days. Tumor sizes were monitored every 2-3 days.
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