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NSC 23766
Cat No.
CEI-0640
Description
A cell-permeable, reversible, and selective Rac1 inhibitor; inhibiting Rac1 activation by the Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam 1 (IC50 = 50 µM) without affecting the closely related GTPases, Cdc42, and RhoA activation. NSC 23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth, etc.
Appearance
Yellow solid
Product Overview
A potent Rac1 inhibitor
CAS No.
733767-34-5
Molecular Weight
298.29
Purity
>97% by TLC
Storage
-20 centigrade
Targets
PTP, PTEN
Molecular Formula
C₂₄H₃₅N₇.3HCl
Chemical Name
N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
Solubility
DMSO (4 mg/ml) or EtOH (0.3 mg/ml)
Shipping Conditions
Gel Pack
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