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Nodularin
Cat No.
CEI-0632
Description
Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC 50 values of 1.8 and 0.026 nM, respectively. It inhibits PP2B only at higher concentrations (IC 50 = 1.8 µM).
Appearance
White solid
Product Overview
A potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A)
CAS No.
118399-22-7
Molecular Weight
810.45
Purity
>98%
Storage
-20 centigrade
Targets
PPP1CA, PPP2R4
Molecular Formula
C41H60N8O10
Chemical Name
Cyclo[3S-amino-9S-methoxy-2S,6E,8S-trimethyl-10-phenyl-4,6- decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)- 3-methyl-D-β-aspartyl-L-arginyl]
Solubility
DMSO (25 mg/ml) or EtOH (25 mg/ml)
Shipping Conditions
Gel pack
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