Description
Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds. NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite branching, serves as an anti-thrombotic, and has anti-inflammatory properties. The role of NNMT overexpression in cancers may be to alter epigenetic methylation patterns in two ways: by lowering the intracellular concentration of SAM, required by methyltransferase enzymes, and by depleting the available NAD+ by transforming nicotinamide to MNA. Sirtuins use NAD+ as a substrate to alter protein acetylation and ribosylation, including histone targets.
Abbr
NNMT, Recombinant (Human)
Source
recombinant N-terminal His- and SUMO-tagged protein expressed in E. coli
Enzyme Commission Number
E.C. 2.1.1.1
Molecular Weight
42.6 kDa
Stability
As supplied, 6 months from the QC date provided on the Certificate of Analysis, when stored properly
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