Description
Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC₅₀ = 180 nM)
Alias
Methylthiohydantoin-DL-tryptophan; Nec-1
Product Overview
A necroptosis inhibitor
Purity
>97% by elemental analysis
Synonyms
Methylthiohydantoin-DL-tryptophan; Nec-1
Molecular Formula
C₁₃H₁₃N₃OS
Chemical Name
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Shipping Conditions
Gel pack
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