Description
Streptokinase (SK) is an enzyme secreted by several species of streptococci that can bind and activate human plasminogen. SK is used as an effective and inexpensive thrombolysis medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. Streptokinase belongs to a group of medications known as fibrinolytics, and complexes of streptokinase with human plasminogen can hydrolytically activate other unbound plasminogen by activating through bond cleavage to produce plasmin.
Abbr
SK (Streptococcus hemolyticus)
Source
Streptococcus hemolyticus
Applications
Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.
Appearance
Appearance (Color): Conforms to Requirements Off-White to Light Yellow to Light Beige
Product Overview
Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)
Form
Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.
Enzyme Commission Number
EC 3.4.99.0
Activity
> 3,500 units/mg solid
Unit Definition
One unit will liquify a standard clot of fibrinogen, plasminogen, and thrombin at pH 7.5 at 37 °C in 10 min.
Synonyms
Streptokinase; SK; EC 3.4.99.0
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