Description
In enzymology, a tyrosine decarboxylase (EC 4.1.1.25) is an enzyme that catalyzes the chemical reaction:L-tyrosine↔ tyramine + CO2. Hence, this enzyme has one substrate, L-tyrosine, and two products, tyramine and carbon dioxide. This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. This enzyme participates in tyrosine metabolism and alkaloid biosynthesis. It employs one cofactor, pyridoxal phosphate.
Abbr
L-Tyrosine Decarboxylase, Native (Streptococcus faecalis)
Source
Streptococcus faecalis
Applications
L-Tyrosine decarboxylase apoenzyme from Strept oc occus faecalis has been used in a study to purify and characterize tyrosine decarboxylase and aromatic-L-amino-acid decarboxylase. L-Tyrosine decarboxylase apoenzyme from Strept oc occus faecalis has also been used in a study to investigate the stereospecificity of sodium borohydride reduction of tyrosine decarboxylase.
Enzyme Commission Number
EC 4.1.1.25
Activity
<0.005 unit/mg solid (without pyridoxal 5-phosphate), > 0.05 unit/mg solid (with excess pyridoxal 5-phosphate)
Unit Definition
One unit will liberate 1.0 μmole of CO2 from L-tyrosine per min at pH 5.5 at 37°C.
Warnings
Dried cells grown on vitamin B6-deficient medium.
Synonyms
tyrosine decarboxylase; EC 4.1.1.25; L-tyrosine decarboxylase; L-(–)-tyrosine apodecarboxylase; L-tyrosine carboxy-lyase; 9002-09-9
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