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Native Rat Histamine N-Methyl Transferase

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Activity

Size

Price

Qty

Activity50-100 U/mg

Size1 mg

Price$550

Qty

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Cat No.

NATE-0898

Description

(HNMT) is the enzyme which catalyzes the n-methylation of histamine as follows: Histamine + S-Adenosyl methionine ------> (SAM)methyladed Histamine. The mechanism involves the transfer of an active methyl group from S-Adenosyl methionine (SAM) to histamine. Histamine is present in most of mammalian tissues and HNMT is the enzyme responsible for inactivation of histamine in mammals. Methylation is major route of histamine metabolism. HNMT has been used to measure histamine by radio-enzymatic method. HNMT has been purified from rat kidney. Molecular weight equals 33,400, pH optimum is 8.00-8.25. We have also purified it from bovine kidney which seems to be very similar to rat kidney.

Abbr

HNMT, Native (Rat)

Alias

HNMT

Source

Rat Kidney

Species

Rat

Form

Freeze-dried powder

Enzyme Commission Number

EC 2.1.1.8

Activity

50-100 U/mg

CAS No.

9029-80-5

Molecular Weight

33.4 kDa

Unit Definition

The amount of enzyme which will convert one nanomole of histamine to methyl histamine per hour at pH 8.5 at 37°C.

Optimum pH

8.00-8.25

Stability

Store at -20°C (-4°F)

Synonyms

Histamine N-Methyl Transferase; HNMT; EC 2.1.1.8

"HNMT" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
EXWM-1981	histamine N-methyltransferase	EC 2.1.1.8	9029-80-5		Inquiry