Description
Polymyxin acylase, from Pseudomonas sp. deacylates polymyxin group antibiotics and long-chain fatty acyl groups of proteins. Polymyxin acylase has an affinity for long-chain fatty acyl proteins in human carcinoma cells.
Abbr
Polymyxin Acylase, Native (Pseudomonas sp.)
Applications
Polymyxin acylase, from Pseudomonas sp., is a N-myristoyl cleaving enzyme that has been used to determine the N-myristoyl peptide sequence and may be useful in cancer research since it has antitumor activity against murine and human tumor cells.
Activity
> 0.1 units/mg solid
Unit Definition
One unit will hydrolyze 1 μmole of N-octanoyl-5-aminovaleric acid per min at pH 8.0 at 37°C.
Synonyms
Polymyxin Acylase; Peptide N-fatty acylase
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