Description
Aconitase catalyses the stereo-specific isomerization of Citrate to Isocitrate via cis-aconitate in the tricarboxylic acid cycle. Aconitase is inhibited by cyanide, sulfide and copper and mercury at low concentRations. It is competitively inhibited by trans-aconitate. Aconitase contains an internal Fe-S cluster which is responsible for its activity.
Abbr
Aconitase, Native (Porcine)
Applications
Aconitase may be usefull in diabetes research as well as to study structural conservation between iron-responsive element binding proteins (IRE-BP) and isomerases .
Product Overview
Crude preparation containing aconitase activity
Enzyme Commission Number
EC 4.2.1.3
Unit Definition
One unit will convert 1.0 μmole of Citrate (via cis-aconitate) to Isocitrate per min at pH 7.4 at 25°C.
Synonyms
cis-aconitase; aconitase; Citrate hydro-lyase; Citrate (Isocitrate) hydro-lyase; EC 4.2.1.3; 9024-25-3; aconitate hydRatase;
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