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Native Human Plasmin
Cat No.
NATE-0598
Description
Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes. Plasmin exhibits preferential cleavage at the carboxyl side of lysine and arginine residues with higher selectivity than trypsin. Converts polymerized fibrin into soluble products.
Abbr
PLG, Native (Human)
Alias
plasmin; PLG
Source
Human plasma
Species
Human
Applications
A complex between plasmin and an inhibitor has been isolated in a study via affinity chromatography from urokinase-activated human plasma. It has also been used in a study to investigate activation of human epithelial sodium channel (ENaC) by plasmin and chymotrypsin.
Product Overview
Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes.
Form
Lyophilized powder containing sodium phosphate, mannitol, and NaCl.
Enzyme Commission Number
EC 3.4.21.7
Activity
> 2.0 units/mg protein
CAS No.
9001-90-5
Unit Definition
One unit will produce one μmole of p-Nitroanilide from D-Val-Leu-Lys-p-Nitroanilide per minute at pH 7.5 at 37°C.
Optimum pH
8.5
Optimum temperature
37°C with rapid inactivation at 56°C
Storage
−20°C
Pathway
Activation of Matrix Metalloproteinases, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Degradation of the extracellular matrix, organism-specific biosystem
Function
apolipoprotein binding; cell surface binding; peptidase activity; protein binding; protein domain specific binding; serine-type endopeptidase activity
Synonyms
fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3.4.21.7; 9001-90-5; PLG
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