Description
Neutrophils, also known as neutrophilic polymorphonuclear leukocytes, are the major class of white blood cell in human peripheral blood. They, have a multilobed nucleus and neutrophilic granules, and are phagocytes and have an important role in engulfing and killing extracellular pathogens. The neutrophil form of elastase is 218 amino acids long, with two asparagine-linked carbohydrate chains. Current studies show that both Cathepsin G and Neutrophil Elastase are key enzymes for tissue injury caused by activated neutrophils, such as occurs in Acute Lung injury.
Abbr
ELA2, Native (Human)
Applications
Clinical research, life science and diagnostic manufacturing uses
Form
Liquid; 0.05 M sodium acetate, 0.6 M sodium chloride, pH 5.5
Enzyme Commission Number
EC 3.4.21.37
Activity
> 25 U/mg protein; > 40 U/mL
Concentration
1.0 - 1.5 mg/ml
Unit Definition
One unit will hydrolyze one micromole of methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37°C and pH 7.5.
Synonyms
ELANE; elastase; EC 3.4.21.37; leukocyte elastase; ELA2; elastase 2; neutrophil elaszym; serine elastase; lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elaszym; granulocyte elastase
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