Description
Cathepsin L (EC 3.4.22.15, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has been reported in many organisms including fish, birds and mammals.
Abbr
CTSL, Native (Human)
Applications
The most powerful of the lysosomal proteinases. It has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates.
Form
Solution in in 20 mM malonate, pH 5.5, 1 mM EDTA, and 400 mM NaCl.
Enzyme Commission Number
EC 3.4.22.15
Activity
> 0.5 units/mg protein
Unit Definition
One unit will hydrolyze 1.0 μmole of Z-Phe-Arg-AFC per minute at pH 5.5 at 25°C.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Endosomal/Vacuolar pathway, organism-specific biosystem
Function
collagen binding; cysteine-type peptidase activity; histone binding
Synonyms
cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2
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