Description
Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, but it is most closely related to other immune serine proteases, such as neutrophil elastase and the granzymes. Cathepsin G may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. It also localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
Abbr
CTSG, Native (Human)
Appearance
Clear, colorless solution
Enzyme Commission Number
EC 3.4.21.20
Specificity
> 5 U/mg protein
Unit Definition
One unit will hydrolyze one micromole of succinyl-alanine-alanine-proline-phenylalanine-p-nitroanilide per minute at 37°C and pH 7.5.
Pathway
ACE Inhibitor Pathway, organism-specific biosystem; Activation of Matrix Metalloproteinases, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem
Function
heparin binding; peptidase activity; serine-type endopeptidase activity
Synonyms
CTSG; cathepsin G; CG; CATG; EC 3.4.21.20; chymotrypsin-like proteinase; neutral proteinase
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