Description
Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene. PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1).
Abbr
tPA inhibitor, Native (Erythrina spp)
Source
Seeds of an Erythrina spp
Applications
To inhibit serine proteases such as tissue plasminogen activator (thrombosis), and to affinity purify t-PA from melanoma cells.
Activity
> 700 U/mg protein
Unit Definition
One unit of inhibitory activity is defined as that amount of inhibitor that will inhibit one fluorometric unit of ETPAI by 50%.
Synonyms
t-Plasminogen activator inhibitor; tPA inhibitor
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