Description
In enzymology, an L-amino acid oxidase (LAAO) (EC 1.4.3.2) is an enzyme that catalyzes the chemical reaction:an L-amino acid + H2O + O2↔ a 2-oxo acid + NH3 + H2O2. The enzyme was first described in 1944 by A. Zeller and A. Maritz. Not only are LAAOs quite variable in terms of molecular mass, they also vary widely regarding stability. In a similar vein, this enzyme performs in a myriad of biological activities including apoptosis-induction, edema-induction, hemorrhaging, and inhibition or induction of platelet aggregation.
Abbr
LAAO, Native (Crotalus atrox)
Source
Crotalus atrox (Western Diamondback Rattlesnake)
Applications
L-amino acid oxidase is used to convert L-amino acids to their corresponding α-keto acids. This product is from Crotalus atrox. One unit will oxidatively deaminate 1.0 μmole of L-phenylalanine per min at pH 6.5 at 37°C. L-amino acid oxidase, from Creative Enzymes, has been used in leucine aminopeptidase (LAP) activity assays
Enzyme Commission Number
EC 1.4.3.2
Activity
> 0.10 unit/mg solid
Unit Definition
One unit will oxidatively deaminate 1.0 μmole of L-phenylalanine per min at pH 6.5 at 37°C. (L-Leucine is deaminated at the same rate at pH 7.8 at 37°C.)
Synonyms
L-amino acid oxidase; LAAO; L-AAO; EC 1.4.3.2; 9000-89-9; ophio-amino-acid oxidase; L-amino-acid:oxygen oxidoreductase (deaminating)
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