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Native Clostridium tetani Tetanolysin
Cat No.
NATE-0693
Description
Tetanolysin is a toxin produced by Clostridium tetani bacteria. Its function is unknown but it is believed to contribute to the pathogenesis of tetanus. The other C. tetani toxin, tetanospasmin, is more definitively linked to tetanus. Tetanolysin belongs to a family of protein toxins known as cytolysins which bind to cholesterol. Cytolysins form pores in the cytoplasmic membrane that allows for the passage of ions and other molecules into the cell. The molecular weight of tetanolysin is approximately 55 kDa daltons.
Abbr
Tetanolysin, Native (Clostridium tetani)
Alias
Tetanolysin
Source
Clostridium tetani
Applications
Tetanolysin has been used to analyze the formation of lytic pores in red blood cells (RBCs). It has also been used to permeabilize infected RBCs.
Product Overview
Hemolytic activity of tetanolysin is determined using 2.5% rabbit red blood cells at 37°C for 40 min.
Form
lyophilized powder containing sodium chloride and sodium acetate
Molecular Weight
55 kDa
Storage
2-8°C
Buffer
When reconstituted with 100 μl of sterile water the concentration is 1 μg/μl in 40 mM sodium phosphate buffer, pH 7.2, containing 200 mM NaCl.
Synonyms
Tetanolysin
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